The season three finale—which creator Sam Levinson confirmed is also the show’s end—saw Zendaya’s Rue dying of an accidental overdose after she unknowingly took a Percocet laced with fentanyl.
For the actress, the finale marked the end of a major chapter in her life.
“I just want to say thank you,” Zendaya said to the cast and crew in a behind-the-scenes look at the episode. “I’m incredibly grateful for every single one of you, and many of you have been here from the beginning and watched me grow up. It’s been a pleasure and an honor. Thank you so much.”
Meanwhile, Levinson knows the series wouldn’t have been the same without his star, who won two Emmys for her portrayal of Rue.
“Zendaya’s performance has been so wonderful and layered over the course of these seasons,” he said in the post-show look. “We fell in love with this character, this girl who's flawed, f--ked up, and has a good heart and is trying to do right, at least sometimes.”
As he put it, “It's a blessing to work with talented people and people that you love.”
But when it came to how he wanted to end the HBO show—which has seen Sydney Sweeney, Alexa Demie, Jacob Elordi and Colman Domingo, go through high highs and lower lows—Levinson wanted to shed light on the harsh realities of addiction.
Plus, he wanted to pay homage to Angus Cloud, who died of an accidental overdose in 2023 at the age of 25.
“In the end I wanted to tell an honest story about addiction,” he reflected. “I also wanted to tell a story about grief and the emotional turmoil that it can create.”
Because for the 41-year-old, Rue’s story strikes a personal chord.
“This is a real show about a real problem that we have in this country, and that's addiction,” he said. “People relapse, they f--k up, they're not ready to get clean, and they weren't dying like they are now with the influx of fentanyl into this country. I can say with absolute certainty that if I was going through what I went through when I was younger now I wouldn't be here either.”
Which is why Levinson felt there was “no reason to sugarcoat it,” he explained. “I wanted to tell this story for Angus, and for people who weren't granted a second chance.”
Meanwhile, Domingo’s character avenged Rue’s death by killing her dealer in a Wild West worthy shootout then found peace on the isolated farm as a way of honoring her.
“What I was thinking about in the homestead scene,” Domingo explained, “was how to put light around someone's existence.”
And for him, Ali’s line of, “Believe in the poetry,” is one that has resonated far beyond the screen.
“I quote Ali a lot,” he said. “It’s that thing you can’t touch—poetry is in the trees, the flowers, in moments. ‘Life is poetry,’ and you got to believe in that and give yourself over to that.”
For more shows that had shocking character exits, some of which were written as deaths as tragic as Rue's, read on.
The Rookie's corrupt lawyer Monica Stevens was no novice when it came to escaping death. "She's escaped multiple assassinations," actress Bridget Regan recounted to TV Insider of her character's four-season journey, "and prison time and being thrown in a woodchipper."
So when the attorney met her end on an April 2026 episode, "I wasn’t surprised," Regan noted. "I thought, 'Fair enough.' She’s had an amazing run, four years on this show. I’m only filled with gratitude."
After making her big break on Dancing With the Stars and landing a starring role in Chicago and Broadway, the Utah native announced season five of the hit Hulu reality show will be her last as she's moving on to other professional projects.
Dr. Samira Mohan is checking out of The Pitt. Actress Supriya Ganesh will not be returning for season three of the HBO Max drama, Variety reported in April.
The exit isn't so shocking to fans given that Ganesh's character has been planning to take on a new residency program at another medical center.
The crime procedural said goodbye to Director Leon Vance (played by Rocky Carroll) in a March 2026 episode, 18 years after the leader's debut in season five. During the 500th episode, Vance was killed in a shooting with a corrupt agent and welcomed to heaven by late Chief Medical Examiner Donald "Ducky" Mallard (played by Adam Campbell).
Mehcad Brooks shocked fans in 2025 when it was revealed he was leaving the NBC crime drama ahead of season 25.
Brooks, who joined the show in 2022, portrayed Detective Jalen Shaw for three seasons.
Kevin McKidd and Kim Raver, who have played Dr. Owen Hunt and Dr. Teddy Altman respectively for nearly 20 years, shocked fans with news that they are leaving the medical drama, with their final episode being the season 22 finale May 7, 2026.
Jenna Lyons announced she will not be returning for The Real Housewives of New York City's 16th season.
"The rumors …..Are true," the former J. Crew Creative Director wrote on Instagram Nov. 21. "I was grateful to be asked to join season 16 of RHONY 'as a friend of '- knowing my personal life was not really available to be filmed, we agreed that made sense."
The fashion icon—who joined the Bravo series for season 14 in 2022—explained that she later realized being a supporting castmember wasn't for her.
"And after thinking it through I have made the difficult decision not return to the show," she continued. "I would be the oldest and only openly gay woman on the show and feel like this is an opportunity for a new dynamic to emerge."
After nine seasons, the A-list realtor is done selling mega-mansions on the Netflix reality show.
“I’ve gotten to a place where I don’t need the show financially,” Chrishell announed in November via social media. “I’m lucky to have other forms of employment, because it’s no longer good for my mental health.”
Jax Taylor announced he will not be returning to The Valley for season three amid growing concern from fans about his behavior during the show’s second season.
“Right now, my focus needs to be on my sobriety, my mental health, and coparenting," the Bravo star—who is embroiled in a nasty divorce from estranged wife Brittany Cartwright—shared in July 2025. "Taking this time is necessary for me to become the best version of myself—especially for our son, Cruz.”
Michael Longfellow, Emil Wakim & Devon Walker, Saturday Night Live
The Saturday Night Live stars all announced within days of each other that they would not be returning for the sketch comedy series' 51st season.
Longfellow and Walker each spent three seasons on SNL while Wakim exited after just one season.
Weeks after Longfellow, Walker and Wakim left SNL, longtime fan-favorites Gardner and Nwodim also confirmed they would not be returning for season 51 after eight and seven seasons, respectively.
Sofia Mattsson exited the long-running soap opera in summer 2025 after seven years playing Sasha Gilmore. Her character left Port Charles for Paris.
The Pitt star Tracy Ifeachor walked away from the hit HBO Max series after the medical drama's breakout first season.
"It was an absolute privilege to play Dr. Heather Collins in such a groundbreaking season and piece," the actress posted on Instagram July 10. "Thank you to everyone who has watched & supported Season 1 & shared their stories with me."
While fans maybe should have been aware that the days were numbered for Pedro Pascal's Joel Miller, considering his April 2025 death was quite similar to how it unfolded in The Last of Us Part II, the 2020 video game season two of The Last of Us is based on, the moment his character was brutally impaled still stunned.
Pascal, meanwhile, who also died onscreen in Game of Thrones and Buffy the Vampire Slayer, took his game over status in stride. "I get killed a lot," he joked to Entertainment Weekly. "I like to die."
After what he dubbed "one wild adventure," Peter Krause officially extinguished his role as 9-1-1's Los Angeles Fire Department captain Bobby Nash on an April 2025 episode of the procedural drama.
“Bobby Nash was written in sacrifice, and he was built for this,” Krause wrote in a statement to the Hollywood Reporter. “First responders risk their lives on the job so that others can see another day. His story arc honors them.”
Killing off the somewhat tormented, but beloved, firefighter was certainly a hot topic, showrunner Tim Minear acknowledged to Variety, "but after eight years, it just felt like, if we have any hope of creating stories going forward that have actual stakes, then someone's got to die."
Paige DeSorbo announced in June 2025 that she was walking away from the Bravo series after seven seasons.
"You’ve seen me grow up over these last 7 summers. I’ll always be grateful for the memories, the community, and the opportunities this wild ride has brought me," the Giggly Squad podcast cohost shared with fans on Instagram. "But like all good things (and some bad decisions), it’s time for this chapter to close."
The French actress confirmed she would not return for the hit Netflix series' fifth season in April 2025.
"After an incredible journey, I’ve made the decision to step away from Emily in Paris,” she wrote in an April 23 Instagram post, alongside pictures of her and her former castmates on set. “It has been a truly wonderful experience, one filled with growth, creativity, and unforgettable memories.”
Ahead of The Sex Lives of College Girls' third season, Reneé Rapp announced she would be leaving the Max series.
"College Girls moved me out to LA and introduced me to some of my favorite people," she wrote on social media in July 2023. "2 and a half years later—it's given me y'all and this community."
The show's co-creator Mindy Kaling also confirmed Rapp's exit. "We love @reneerapp so much and of course will be so sad to say goodbye to Leighton Murray!" Kaling wrote on her Instagram Stories before referencing Rapp's thriving music career. "We can't wait to see our friend on tour!!"
More than a year after Kevin Costner was rumored to have unexpectedly walked away from the hit Paramount drama after four and a half seasons, he confirmed in June 2024 that he will not return to finish out the series' fifth and final season.
After 19 years as Meredith Grey, Ellen Pompeo scrubbed in for the last time as a series regular on the ABC drama in February 2023.
"I gotta mix it up a little bit," Pompeo explained on The Drew Barrymore Show in December 2022, though she has already returned for a May guest appearance and continues narrating the series. "I'm 53, my brain is like scrambled eggs. I gotta do something new. You can't do The New York Times crossword puzzle every single day."
But she's not gone for good. Pompeo still pops in and out of Grey Sloan Memorial Hospital.
Batman vs. Superman star Henry Cavill revealed he would be stepping away from the Netflix fantasy drama after its third season—with the announcement that Liam Hemsworth will assume the role of Geralt for season four, and potentially beyond.
"My journey as Geralt of Rivia has been filled with both monsters and adventures," Cavill wrote on Instagram in October 2022. "Alas, I will be laying down my medallion and my swords for Season 4."
Original castmember Jesse Lee Soffer turned in his badge in 2022, saying goodbye to his beloved character Detective Jay Halstead role after 10 seasons.
"To create this hour drama week after week has been a labor of love by everyone who touches the show," Soffer said in a statement after his final appearance in the NBC procedural's Oct. 5 episode. "I will always be proud of my time as Det. Jay Halstead."
After five seasons, Damian Lewis departed Showtime's Billions in Oct. 2021.
In Aug. 2021, it was reported that Emily VanCamp hung up her stethoscope for good as she had exited Fox's The Resident.
After three seasons of feeling Charmed, Madeleine Mantock, who played eldest sister Macy on the CW reboot, announced her exit ahead of season four in 2021. Calling the role "an immense privilege," in a statement, the actress shared how much she "enjoyed working with our fantastic producers, creatives, cast and crew."
Turns out Elizabeth Keen never will find out the truth about Raymond Reddington's identity. Megan Boone chose to leave NBC's The Blacklist at the end of season eight, and of course her character was killed off before she had the chance to read the letter that would have revealed everything. Boone marked the end of Liz's journey in 2021 with an Instagram post in which she called the experience "a dream."
Season two of Bridgerton was down one duke. Rege-Jean Page became the breakout star of Netflix's massive hit drama, and then broke hearts all over the place when it was announced that he would not be returning for the second season in 2021.
"I signed up to do a job and I did the job and then I did some other jobs," he later explained to Vanity Fair. "That's it. That's the story. I wish it was more glamorous than that."
Ruby Rose made her debut in 2018's Arrowverse crossover and then starred in one season as the titular Batwoman (a.k.a. Kate Kane) in the CW drama—making history as the first lesbian superhero to headline their own show, as Batwoman came out of the closet in a major TV moment—before announcing her exit just two days after the season one finale aired in 2020. The role was eventually replaced with Javicia Leslie as Ryan Wilder, a new character set to take control of the Batcave in season two.
Later on in season two, Kate got a bit of a face swap and returned played by Wallis Day.
America Ferrera decided to exit Superstore at the end of season five in 2020, leaving Cloud 9 without a manager and the show without a lead. She ended up appearing in the first two episodes of season six due to the pandemic, and then when season six was deemed the end, she returned for the series finale to give Amy and Jonah (Ben Feldman) the happy ending they deserved.
In the 2019 season four finale of the Syfy series, Jason Ralph's character Quentin completed his quest to save Eliot (Hale Appleman), but sacrificed himself in the process. While the show does feature dead characters—it's called The Magicians after all—Ralph did not return for the fifth and final season.